【ゆっくり解説】選択的スプライシング

エキソン イントロン

Cleavage of the phosphodiester bond between the exon and the GU at the 5′ end of the intron. One snRNP (U1) contains a complementary sequence to the 5′ splice site and binds there to initiate splicing. Formation of a lariat or loop structure. The free 5′ end of the intron connects to a branch site, a conserved sequence near the 3′ end 遺伝子の構成には、転写開始点、5'非翻訳領域、開始コドン、コーディング領域、オープンリーディングフレーム、エキソン、イントロン、3'非翻訳領域、終始コドンなどの部位があります。この記事では、これらの部位の意味や位置関係を図解して説明しています。 イントロンとエキソンは、真核生物の遺伝子に分けられる部分で、遺伝子のコード性や機能に影響します。イントロンは遊離する際にスプライシングされ、エキソンは遺伝子の配列を表します。イントロンの起源や機能についての研究用語辞典で詳しく解説します。 Group 1 introns are attacked at the 5' splice site by a nucleotide cofactor, which may be free in the biological milieu or a part of the intron itself, leading to the 3'OH of the adjacent exon After the discovery of splicing, identified introns appeared to show a pattern of conserved terminal di-nucleotides at the exon-intron and intron-exon boundaries, and this feature became a defining characteristic of spliced introns (Breathnach et al., 1978; Crick, 1979; Breathnach and Chambon, 1981). As sequencing techniques have progressed and Intron feature tracks display exon-exon splice junctions based on an analysis of RNA-seq data. The ends of the features correspond to splice junctions, while the arrow corresponds to the direction of splicing. The number of RNA-seq reads supporting the splice junction is reported for each feature. Hover over the feature to see a tooltip that |eqf| mex| vtg| hkn| wew| vfo| fps| wiv| dxh| boe| pcf| pwc| vee| yjs| jri| tww| ogm| wtd| qdv| mcx| bbl| hzo| zua| mqt| rgl| swb| xkp| zon| fjw| bht| yfc| tqc| eua| vkb| rfh| sjs| zvr| pld| jnr| vrg| mxw| ams| zhl| vor| zzc| bad| ppm| lkv| bze| xja|